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Equal concentrations of total RNA (10 g) were size-separated on 1.2% agarose-2.2 M formaldehyde gels and blotted onto Hybond N+ membranes (Amersham Biosciences)

Its findings the safe dose range, how the compound behaves in humans, early signs of biological activity feed directly into Phase 2, where the drug is studied in patients for the first time, and therefore for the first time therapeutic efficacy is tested and the most optimal dose is investigated

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